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Howard M. Temin. Ph.D. (1934-1994). American Scientist & Nobel Laureate in Physiology or Medicine (1975). First Day Cover Signed, being a dedication to the Mayo Brothers, postmarked Rochester, Minnesota, September 11, 1964. Signed on the front: "Howard M. Temin". Normal aging. In fine condition.
He shared the Nobel Prize for describing how tumor viruses act on the genetic material of the cell through reverse transcription. This upset the widely held belief at the time of the "Central Dogma" of molecular biology posited by Nobel laureate Francis Crick, one of the co-discoverers of the structure of DNA (along with James Watson and Rosalind Franklin). Crick, along with most other molecular biologists of the day, believed genetic information to flow exclusively from DNA to RNA to protein. Temin showed that certain tumor viruses carried the enzymatic ability to reverse the flow of information from RNA back to DNA using reverse transcriptase. This phenomenon was also independently and simultaneously discovered by David Baltimore, with whom Temin shared the Nobel Prize.
The discovery of reverse transcriptase is one of the most important of the modern era of medicine, as reverse transcriptase is the central enzyme in several widespread human diseases, such as HIV, the virus that causes AIDS, and Hepatitis B. Reverse transcriptase is also an important component of several important techniques in molecular biology and diagnostic medicine, such as reverse transcription polymerase chain reaction (RT-PCR). Temin received the National Medal of Science in 1992.
The autograph comes with a letter of authenticity as to its origin, history and authenticity.
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